- Platelet-rich fibrin (PRF) concentrates growth factors from your own blood and applies them to implant, extraction, and bone graft sites to accelerate tissue repair.
- A 2022 systematic review in Clinical Oral Implants Research found PRF significantly reduces post-operative pain and healing time after tooth extraction compared to conventional healing.
- PRF uses no synthetic additives or donor blood — it is prepared from the patient's own sample during the appointment.
- Centre Dental routinely includes PRF in implant placements, bone grafts, and complex extractions at no additional charge for qualifying cases.
Dental procedures involving bone or deep tissue — implant placement, tooth extraction, bone grafting, gum surgery — heal on a predictable biological timeline. PRF (platelet-rich fibrin) therapy is one of the most evidence-backed tools for accelerating that timeline using materials entirely derived from your own body.
TL;DR — Quick Summary
Platelet-rich fibrin (PRF) concentrates growth factors from your own blood and applies them to implant, extraction, and bone graft sites to accelerate tissue repair.
What Is PRF?
A small blood sample (10–20 mL) is drawn at the start of your appointment and spun in a centrifuge for 12–14 minutes. The centrifuge separates blood into layers; the middle layer — rich in platelets, growth factors, and fibrin — is concentrated and applied as a membrane or gel to the treatment site. Key growth factors concentrated in PRF include:
- Platelet-derived growth factor (PDGF) — stimulates cell proliferation and wound healing
- Transforming growth factor beta (TGF-β) — promotes collagen synthesis and tissue remodeling
- Vascular endothelial growth factor (VEGF) — supports new blood vessel formation
- Insulin-like growth factor (IGF) — accelerates bone and soft tissue regeneration
What the Evidence Shows
- 2022 systematic review in Clinical Oral Implants Research: PRF significantly reduces post-operative pain, swelling, and socket healing time after tooth extraction vs. conventional healing
- 2021 meta-analysis in the Journal of Periodontology: PRF at implant sites improves marginal bone stability at 12 months vs. non-PRF controls
- 2020 review in the International Journal of Oral & Maxillofacial Surgery: PRF reduces dry socket incidence after third molar extractions
"PRF is not a miracle additive — it is a way of concentrating the biology already in the patient's body and delivering it precisely where healing needs to happen. For complex cases, it materially changes the recovery curve." — Dr. John Shi, D.D.S., Centre Dental NYC
When We Use PRF at Centre Dental
We routinely incorporate PRF into our dental implant placements, bone grafting procedures, complex extractions (including wisdom teeth removal), and sinus lift procedures. For full-arch All-on-X cases, PRF membranes cover the surgical sites before suturing.
Cases where PRF is particularly beneficial:
- Implants placed in sites with prior infection or limited bone density
- Simultaneous implant placement and bone grafting
- Patients with slower healing due to age or systemic conditions
- Complex third-molar extractions involving bone removal
- Ridge preservation after extraction to maintain volume for future implants
What to Expect
- Blood draw: 10–20 mL from your arm at the start of the appointment — similar to a routine lab draw
- Centrifuge: 12–14 minutes of processing while the main procedure preparation begins
- Application: PRF membrane or concentrate placed in the surgical site before closure
- No additional appointment time — PRF preparation runs within your existing procedure window
Not every procedure requires PRF. If you are planning implant placement, a bone graft, or a complex extraction, ask about PRF at your consultation. Contact us to schedule.
